Abstract:
Until today, the contemporary Adaptive Immunology is using Clonal Selection Theory (CST) as a main Theory of Adaptive Immunology for explanation of how Adaptive Immune system is working in mammals.
But after 5 years (2010-2015) of his theoretical research results did show that CST is totally wrong.
He have theoretically discovered 2 novel main mechanisms which will change whole Molecular Adaptive Immunology Conception and Theories and will bring very powerful novel Super-Antibody Technology for curing of all of Infectious Diseases and Cancer! His novel Discoveries are:
- (First Discovery) All of Naïve B-cells (NBCs) which are produced in Bone Marrow are the same structure! There is not Random Rearrangements as CST is alleging! All of the NBC’s have on membrane surfaces the same IgM and IgD, which are not affine to any AE! They are using as a Receptors for interaction with Dendritic Cells (DC) for getting one of the Intraluminal Vesicles (ILV) with Antigen Epitopes (AE) on MHC-2 from Multivesicular Body (MVB) of DC!
Th cells do not have this mechanism! Th cell activation and production of massive Th-cell Cytokines depends quantities (at least 50-to 100) of AE’s on MHC-2) which NBC has got from DC! Th cell connected with small amount of AE’s on DC can’t be activated by DC! Th cells just docking on the DC, but not being activated!
- (Second Discovery) After interaction and activation Th cell by NBC, Th cell is producing massive amount of Cytokines, which are bringing reciprocal activation of NBC. Under Th Cytokines, NBC produces unknown yet enzyme which connects triplets of t-RNAs with activated amino-acids (aa) which are noncovalently connected with affine aa of AE and that way creates short endosomal RNA (e-RNA) in the endosome of NBC! Then with the help of Nuclear Receptor(s) this nascent e-RNA relocates to VDJ section of Heavy Chain (HC) and replace Replicable Module (p-N-D-N-p) of HC DNA and that way V part of HC is coding affine aa to giving AE! I have call this mechanism Reverse Pathway mechanism, which explain why IgG is the first and abundant (75% of all Ig-s in the blood) and affine Ig-s in the body!
His novel Conception and Reverse Pathway Theory scientifically explain all of real processes which are happening in Molecular Adaptive Immunology! Contemporary CST is wrong and have to be replaced with my novel Conception and Reverse Pathway Theory, which will bring a novel and very powerful Super-Antibody Technology for curing of all of Infectious Diseases and Cancer.