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Epigenetic changes play a significant role in both aging and cancer, as alterations in gene expression without changes to the underlying DNA sequence can drive disease progression. As individuals age, these epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, can accumulate and influence cellular processes such as DNA repair, cell cycle regulation, and apoptosis. In cancer, these changes can activate oncogenes or silence tumor suppressor genes, contributing to tumor growth and resistance to treatments. Understanding the connection between aging-related epigenetic changes and cancer development opens up new possibilities for therapies that target these modifications. By reversing or modifying these epigenetic alterations, researchers hope to improve treatment outcomes and prevent cancer in aging populations.
