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Extragonadal germ cell tumors (EGCTs) are rare neoplasms that originate from primordial germ cells outside the gonads, which are the usual site for germ cell development. Unlike the more common testicular and ovarian germ cell tumors, EGCTs can manifest in various locations throughout the body. These tumors exhibit histological similarities to their gonadal counterparts, comprising cells that retain the potential to differentiate into multiple tissue types. EGCTs primarily affect adolescents and young adults, with a slight male predominance. The exact etiology of these tumors remains unclear, and their occurrence at extragonadal sites poses diagnostic challenges. Common extragonadal locations for EGCTs include the mediastinum, retroperitoneum, and central nervous system. Diagnosis involves a combination of clinical evaluation, imaging studies, and histopathological analysis of biopsy specimens. Serum tumor markers, such as alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (β-hCG), are often elevated in EGCTs, aiding in the diagnostic process. Treatment strategies for EGCTs typically involve a multidisciplinary approach, including surgery, chemotherapy, and radiation therapy, depending on the tumor's location, stage, and histology. The prognosis varies based on these factors, with early detection and comprehensive treatment contributing to favorable outcomes. EGCTs highlight the diverse nature of germ cell tumors and underscore the importance of considering extragonadal sites in their diagnosis and management. Ongoing research aims to enhance our understanding of the molecular mechanisms underlying these tumors, potentially leading to improved diagnostic methods and targeted therapies in the future.
