Gastric adenocarcinoma is a type of cancer that originates in the lining of the stomach. This malignancy typically develops from the glandular cells in the stomach lining, which produce mucus and other fluids aiding in digestion. Gastric adenocarcinoma is the most common form of stomach cancer, representing the majority of cases. The exact cause of gastric adenocarcinoma is not fully understood, but factors such as chronic infection with Helicobacter pylori bacteria, long-term inflammation of the stomach lining, smoking, and certain genetic predispositions are believed to contribute to its development. Additionally, dietary habits, including the consumption of processed and preserved foods, may influence the risk of developing this cancer. Symptoms of gastric adenocarcinoma can be vague and may include indigestion, abdominal discomfort, unintentional weight loss, and a feeling of fullness after eating small amounts. Unfortunately, these symptoms often manifest in the later stages of the disease, making early detection challenging. Diagnosis typically involves a combination of imaging studies, such as endoscopy and CT scans, along with biopsies to confirm the presence of cancerous cells. Treatment options for gastric adenocarcinoma depend on the stage of the cancer but may include surgery, chemotherapy, and radiation therapy. In advanced cases, a multidisciplinary approach is often necessary to address the complex nature of the disease. Prognosis for gastric adenocarcinoma varies and is influenced by factors such as the extent of tumor spread, the patient's overall health, and the success of treatment. Despite advancements in medical care, the prognosis for advanced stages of gastric adenocarcinoma remains guarded.