Cancer trends vary globally due to environmental, genetic, and socioeconomic factors. In high-income countries, advanced healthcare systems enable better detection, leading to higher incidence rates but lower mortality due to effective treatment. Conversely, low-income regions face challenges such as limited access to medical care and late-stage diagnoses, resulting in higher death rates. Lung, breast, and colorectal cancers are prominent globally, while cervical cancer remains a significant concern in underprivileged areas. Environmental exposures, dietary patterns, and lifestyle habits also contribute to regional variations in cancer incidence. Collaborative global efforts are essential to addressing these disparities, focusing on equitable healthcare access, improving diagnostic infrastructure, and implementing preventive measures tailored to local needs, ultimately reducing the worldwide cancer burden.