Metastasis is one of the most devastating aspects of cancer progression, involving the spread of cancer cells from the primary tumor to distant organs. This complex process requires cancer cells to invade surrounding tissues, enter the bloodstream or lymphatic system, and establish secondary growths in new locations. Metastatic cells evade immune surveillance and often develop resistance to treatment. Identifying the molecular drivers behind metastasis is crucial for developing therapies that can prevent or reverse this spread. Targeting specific molecules involved in cell migration, adhesion, and immune evasion could halt the metastatic process, providing new opportunities for improving survival rates in cancer patients.