Woolly Monkey Sarcoma Virus (WMSV) is a retrovirus that primarily affects woolly monkeys, a species native to the Amazon rainforest. This virus belongs to the family Retroviridae and is closely related to other primate retroviruses. WMSV is known for its ability to induce sarcomas, which are malignant tumors arising from connective tissues such as bone, cartilage, and muscle. Discovered in the mid-20th century, Woolly Monkey Sarcoma Virus has been extensively studied to understand its virology and the mechanisms underlying its oncogenic properties. The virus is transmitted through bodily fluids, and infection can lead to the development of sarcomas in various organs and tissues of infected monkeys. The genome of WMSV contains genetic information that allows it to integrate into the host's DNA, leading to the dysregulation of cellular processes and the initiation of tumor formation. The virus's oncogenic potential has made it a valuable model for studying the molecular mechanisms of cancer development. While WMSV primarily affects woolly monkeys, there is no evidence to suggest that it poses a significant threat to human health. Nevertheless, research on this virus has provided valuable insights into retroviral oncogenesis and has contributed to our broader understanding of cancer biology. Ongoing studies continue to explore the intricate interactions between Woolly Monkey Sarcoma Virus and its host, shedding light on potential therapeutic strategies for retrovirus-associated cancers.