Biodentx A bio intelligent self healing dental material enabling true enamel regeneration through peptide guided biomineralization

Title : Biodentx A bio intelligent self healing dental material enabling true enamel regeneration through peptide guided biomineralization

Abstract:

Enamel has long been regarded as a non-regenerating tissue — once lost; its structural integrity is permanently compromised. Current restorations only replace lost tissue superficially, leaving patients vulnerable to recurrent caries and eventual failure. With the convergence of biotechnology and dental materials science, this paradigm is being redefined. There is a growing demand for restorative solutions that revive tooth biology rather than simply patch defects.
BioDentX incorporates a hybrid regenerative system consisting of:

• Bioactive glass for sustained release of calcium, phosphate, and fluoride ions
• Specialized biomimetic peptides to trigger mineral nucleation and dentin matrix regeneration
• A smart adhesive polymer scaffold that secures structural support while maintaining a pro-regenerative microenvironment.

This design has undergone feasibility validation at Technology Readiness Level 2, and the concept was awarded 2nd Place in the Manipal Bio Incubator National Bio Innovation Hackathon, highlighting its scientific promise and translational potential.
Early conceptual modeling indicates the system’s ability to reverse early carious demineralization, significantly decrease restoration failure, and preserve native tooth structure shifting the field toward sustained vitality-based care. Planned in-vitro studies (ion-release profiling, microhardness recovery, simulated caries models) will establish clinical feasibility. With further development, BioDentX could pioneer accessible regenerative dentistry, especially in high-caries, resource-limited populations.
Keywords: Regenerative Dentistry, Self-Healing Restorative, Enamel Regeneration, Bioactive Peptides, Biomimetic Materials, Dental Biotechnology.

Biography:

Afra Samreen is a third-year Bachelor of Dental Surgery student at Rajiv Gandhi Institute of Health Sciences, India, with a growing interest in regenerative dentistry and biomimetic dental materials. She was awarded second Place at the Manipal BioIncubator National BioInnovation Hackathon for developing BioDentX, a self-healing restorative material aimed at reviving tooth biology. She is passionate about translating biotechnology into clinical dentistry to improve access to minimally invasive, regenerative oral care in high-disease-burden communities.