Understanding how living systems repair and renew themselves underpins much of modern tissue engineering. Biological models of regeneration examine how species such as salamanders, zebrafish, and planarians naturally regrow limbs, spinal tissue, or entire organs. These models reveal key molecular pathways—such as Wnt, BMP, and FGF signaling—that are conserved across species and can be manipulated in human cells for therapeutic purposes. By studying cellular plasticity, immune modulation, and scaffold-independent regeneration, researchers identify principles applicable to human healing. Biological models of regeneration inform the design of synthetic systems, gene circuits, and scaffold-free regeneration strategies, bringing biologically inspired insights into clinical frameworks and strengthening the foundation for transformative therapies.
Title : The era of artificial intelligence (AI) and its use in regenerative medicine
Vasiliki E Kalodimou, European University-Cyprus Ltd, Cyprus
Title : AI-integrated high-throughput tissue-chip for space-based biomanufacturing applications
Kunal Mitra, Florida Tech, United States
Title : Stem cells for human disease modelling and potential for tissue repair
Patrizia Ferretti, UCL Great Ormond Street Institute of Child Health, United Kingdom
Title : Advanced 3D tissue models: Pioneering tools for investigating health and disease
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Title : The role of gingival fibroblasts in periodontal diseases and regeneration
Katarzyna Gawron, Medical University of Silesia in Katowice, Poland
Title : Personalized and Precision Medicine (PPM): A unique healthcare model via pathology-related modelling and bi-odesign-inspired translational applications for the next gen-eration of human healthcare and biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation