HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.

International Summit on Hematology and Blood Disorders

April 27-29, 2023 | Orlando, USA

April 27 -29, 2023 | Orlando, Florida, USA
Hematology 2023

Safety of not withholding Clopidogrel Therapy during the immediate several days pre and post Trans-Urethral Resection of Prostate (TURP) A retrospective cohort study

Ahmed Kamel Abdulhamid, Speaker at Blood Disorders Conference
University of Kerbala, Iraq
Title : Safety of not withholding Clopidogrel Therapy during the immediate several days pre and post Trans-Urethral Resection of Prostate (TURP) A retrospective cohort study

Abstract:

Background and aim: Benign prostatic Hypertrophy or hyperplasia (BPH) is a frequent urological complain particularly in old age individuals. Those patients usually have other risk factors (such as ischemic cardiovascular diseases) for which they might be treated with anti-thrombotic agents chronically. These medicines may induce blood thinning and raise the incidence of haemorrhage. Thus, if those patients needed operative treatment for BPH, they may be at high risk of haemorrhage or its related adverse effects with the usage of anti-thrombotic drugs during the peri-operative time. On the other hand, dis-continuation of these agents can lead to ischemic events in susceptible individuals.

Therefore, this research aims to assess the safety of the continuation of using anti-thrombotic agents throughout the peri-operative duration in patients with prostate surgery in form of Transurethral Resection of Prostate (TURP) only for Benign Prostatic Hypertrophy (BPH).

Methods:  Patients’ notes were reviewed retrospectively. The entire participants were categorized into two categories. First category was on clopidogrel therapy (CTC) for prolong time and the usage of these agents was carried on throughout the peri-operative period. The second category was not on clopidogrel therapy at all (NCTC). Both of these categories had Transurethral Resection of Prostate (TURP) for Benign Prostatic Hypertrophy (BPH). A comparison had been conducted between the two categories with regards to : (i) the amount of blood lost intra-operatively(ii) The duration of operation  (iii)  hematocrit concentration per-operatively (iv) transfused packed red blood cells (PRBC) if needed (v)  clearance of hematuria postoperatively. (vi) Secondary haemorrhage and clot retention after discharge. Pearson Chi-square test, Independent sample t test and test for numeric variables were used as appropriate

Results: The study identified 329 patients.  165 participants in the CTC ( clopidogrel Therapy Category) and 164  in the  NCTC (  Non clopidogrel Therapy Category). It had been revealed that there was no statistically significant difference between the  CTC and  NCTC regarding : (i) the amount of blood lost intra-operatively(ii) The duration of operation  (iii)  hematocrit concentration per-operatively (iv) transfused packed red blood cells (packed RBC) if needed (v)  clearance of hematuria postoperatively. (vi) Secondary haemorrhage and clot retention after discharge (P>0.65).

Conclusion: The continuation of usage of Anti-Thrombotic Therapy (clopidogrel) during peri-operative period in patients with TURP for BPH is a safe practice. It is not associated with high probability of haemorrhage or PRBC transfusion or other adverse effects

What will audience learn from your presentation?

1-It is safe practice to continue the usage of Anti-Thrombotic Therapy (clopidogrel) during peri-operative period in patients with TURP for BPH.

2- This practice is not associated with high probability of haemorrhage or PRBC transfusion or other adverse effects

3-This practice can reduce the complications of anti-platelets withholding such as the ischemic heart diseases

Biography:

Dr Ahmed Kamel Abdulhamid is a Medical Doctor who graduated from the Faculty of Medicine /University of Baghdad/ Iraq. Also, he holds an MSc degree in minimally invasive and Laparoscopic surgery at the Queen Mary University of London. After qualification became a specialist surgeon with a particular interest in Laparoscopic and Minimally Invasive Surgery in urology and general surgery.

Watsapp