Huiqin Yang, ICON Clinical Research Ltd, United Kingdom
Precision oncology plays an essential role for the treatment of solid cancers. Colorectal cancer has emerged as a disease condition where abnormal genetic mutations occur in a group of colorectal cancer patients. Patients with advanced  [....] » Read More
Title : Copper (II) complexes as potential anticancer agents
Salah S Massoud, University of Louisiana, United States
Cancer is the second major cause of deaths in the world and U.S.A. after heart diseases. Platinum-containing drugs such as cisplatin and its second and third generations, which have been approved worldwide in the treatment of various types of human cancers experience serious toxi [....] » Read More
Title : Leveraging blockchain technology, edge computing and federated learning to enhance outcomes in precision medicine
Ingrid Vasiliu Feltes, MEDNAX, United States
Precision medicine is a relatively novel approach that aims to redefine the way we diagnose, treat and prevent disease. It has also evolved at an exponential pace over the last few years and fueled the development of person-centered medicine. This growth has b [....] » Read More
Title : The new horizons in the patient- centered care for understanding of the reasons of its health problems – Psychosynthesis approach
Ewa Danuta Bialek, Institute of Psychosynthesis, Poland
Patient-centered medicine is a unique approach that is becoming ever more dynamic and offers ever more innovative solutions for the treatment of patients. From the classic approach – the focus on the disease, it is focused on the individual patient. From the perspective of [....] » Read More
Title : Hegazy theory for interpretation of human parthenogenesis: A new hypothesis
Abdelmonem Awad Hegazy, Zagazig University, Egypt
Pathogenesis is a mysterious process that occurs very rarely in humans. Despite extreme rarity of its occurrence, the idea should be dismissed at all. Here, we attempt to explain how this rare phenomenon occurs. Understanding this event may help develop a way to start the develop [....] » Read More
Title : The role of CD44v6 as a new immunotherapy target for urothelial cancer
Iris Adriana Maria Lodewijk, Institute of Biomedical Research, Spain
CD44v6 is a splice-variant of the CD44 glycoprotein and has been associated with poor prognosis for cancer patients as well as invasion, migration and metastasis in a wide variety of cancer types. However, none of these associations has been reported for bladder cancer (BC) so fa [....] » Read More
Title : Prevalence of complement factor H (Y402H) gene polymorphism and its impact on the predisposition of Syrians to Age-Related Macular Degeneration and response to Bevacizumab intravitreal injection
Loubna Safar, Damascus University, Syrian Arab Republic
Age-related macular degeneration (AMD) is one of the main causes of blindness worldwide. Complement system activation plays a key role in the chronic inflammation linked to AMD. Complement factor H polymorphism (Y402H) is thought to play a potential role in the predisposition to [....] » Read More
Title : Prevalence, pattern, and genetic diversity of human immunodeficiency virus in children under 10 years of age with acquired immunodeficiency syndrome in South Africa: A systematic review and meta-analysis
Isaiah Phillip Smith, University of KwaZulu-Natal, South Africa
The human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, poses major challenges to healthcare worldwide, especially in children under the age of 10. Sub-Saharan Africa is overwhelmingly suffering unprecedented deaths due to this pandemic [....] » Read More
Title : CRISPR designing your G-rna for CAS 9 genome editing using DNA sensors to detect cerebrospinal fluid morbiditidity in-vitro viral gene transmission
Nisha Mithal , Sri Ramachandra Medical College, India
CRISPR technology has made it easier than ever both to engineer specific DNA edits and to perform functional screens to identify genes involved in a phenotype interest. We will discuss differences between these approaches, and provide updates on how best todesign gRNAs. The ha [....] » Read More
Title : Precision medicine innovations: Key opportunities and challenges
Ogu Chinemerem Joshua, Precision Orthopaedic and Prosthetics, Nigeria
Precision medicine, also known as personalised medicine is a fairly new concept in medicine that seeks to improve the outcome of health care in patients by taking into cognisance genetic makeup and other factors of patients to deliver personalised all inclusive care to patients w [....] » Read More
Title : Physical fitness from the point of view of personalized medicine.
Jaroslav Novak, Charles University , Czech Republic
The cardiorespiratory system is characterized by a high range of effort adaptability. An objective measure of its capacity (cardiorespiratory fitness - CRF) is the maximum oxygen consumption VO2max, often expressed in terms of VO2max/kg per kilogram of body weight. While the aver [....] » Read More
Title : Melatonin: Is it a new light in the treatment of Cervical Cancer?
Barbara Maria Frigieri, Sao Paulo State University (UNESP), Brazil
Cervical cancer is the second most common cancer of women in the world. The treatment for this type of cancer includes chemotherapy, radiotherapy, and in more severe cases surgery is necessary, thus being highly invasive for these women, and so we see the search for new treatment [....] » Read More
Title : Precision Medicine in Southern Africa
Paidamoyo Kachambwa, Mediclinic Precise, South Africa
Africa is known as the origin of humanity; it has been shown that it’s rich genetic variation and disease progression are likely key to understanding pathogenesis of many complex genetic disorders. When considering Precision medicine, understanding this richness has an impa [....] » Read More
Title : How to make a universally defined definition of ‘fever’ and ‘hyperthermia’
Yacob Mathai, Marma Health Centre, India
Today, fever is defined as a temperature above 38 degrees Celsius (100.40 F). The same temperature is used to determine hyperthermia. The temperature of the fever is below 42 degrees, but the temperature of the hyperthermia may be above 42 degrees, but the common factor for fever [....] » Read More
Title : It is incorrect to determine fever and hyperthermia by looking at temperatures above 38 degrees Celsius. Why?
Yacob Mathai, Marma Health Centre, India
Today, fever is determined by looking at temperatures above 38 degrees Celsius (100.40 F). The same temperature is used to determine hyperthermia. Patients with fever and low-temperature hypothermia are more likely to be assessed as hyperthermia when they lie unconscious in the [....] » Read More
Title : Precision diagnostics with omics data in IBS and IBD: a clinical case
Svetlana Lyamina, Moscow State University of Medicine and Dentistry, Russian Federation
It is well known the repertoire of gastrointestinal symptoms is limited; so different conditions can present with the same, or similar, symptoms. It follows that the symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can overlap. It is widely accepted [....] » Read More
Title : Probiotics and ghost probiotics as biotechnological tools in personalized medicine: Opportunities for Africa
Abigarl Ndudzo, Lupane State University, Zimbabwe
The influence of intestinal state on the health of an individual is generating attention for patients and consumers willing to adapt their dietary habits to achieve best well-being and health. The gut microbiome, which is a complex and dynamic microbial community, is important in [....] » Read More
Title : Early metabolomic profiling in IBD: Crohn's disease and ulcerative colitis patients
Svetlana Lyamina, Moscow State University of Medicine and Dentistry, Russian Federation
The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are complex chronic relapsing disorders with component of gut microbiome alteration. Not always standard diagnostics allow to ensure the precise diagnostics for a high-quality selection o [....] » Read More