The development of storage, analytic, and interpretative tools to optimize the transition of increasingly enormous biomedical and genetic data into proactive, predictive, preventive, and participatory health is what translational informatics is all about. The creation of novel methodologies for the integration of biological and clinical data, as well as the expansion of clinical informatics methodology to include biological observations, are all part of translational informatics research. Translational research informatics (TRI) is a sub-domain of biomedical or medical informatics concerned with the use of informatics theory and methodology to translational research. Although there is some overlap with the related topic of clinical research informatics, TRI is more focused on enabling multidisciplinary research to speed clinical outcomes, with clinical trials frequently being the next logical step after translational research.