The science of digital phenotyping is multidisciplinary. Digital phenotyping relies on users continued willingness to allow access to multiple data streams, ranging from on-device sensors to third-party social media, that provide insights into their everyday activity, both during development and thereafter. The promise of digital phenotyping is that this objective measure takes place in the context of a patient's lived experience, reflecting how he or she performs in his or her environment rather than in our clinic. As a clinical tool, digital phenotyping is currently being developed. This is the time for patients, families, providers, and researchers to determine the balance between clinical value and public trust in digital phenotyping.