Bioartificial Organs (BO) are extracorporeal or implanted devices that employ specialized cell populations to perform the functions of organs such as the pancreas or liver. The most favourable bioartificial organ manufacturing technologies is to use combined multi-nozzle three-dimensional printing techniques to automatic assemble personal cells in conjunction with other biomaterials to make exclusive organ substitutes for failed human organs. Organ manufacturing is any procedure which will produce organ substitutes using any available materials, like polymers, cells, metals, etc. In a narrow sense, organ manufacturing is a procedure which will produce bioartificial organs mimicking their counterparts structures, components and functions.
Developmental biology for identifying cell specific markers of stem cells and progenitor cells of the different target cells. Exploration of the potential use of adult stem cells in the formation of human cell lines.
Materials Based Research
The microtechnology to supply clinical quantities of sterile bioartificial organ grafts requires further development. Laboratory and commercial prototypes are going to be needed to maneuver the bioartificial organs presently in clinical trials through the regulatoryc pipeline.
Genetic modification of the different cell lineages permitting the elimination of immunosuppression is a mid term goal.