Despite breakthroughs in interventional, pharmacological, and surgical therapy, organ failure remains the top cause of death worldwide. Since then, beyond human memory, bioartificial organ manufacturing has been a long-term goal. Man-made organs may, in the not-too-distant future, save the lives of people whose kidneys, pancreas, or lungs are failing. The design, modification, growth, and maintenance of living tissues implanted in natural or synthetic scaffolds to enable them to execute complicated biochemical activities, such as adaptive regulation and the replacement of regular living tissues, are all part of bioartificial organs. Healthy human cells (produced from organ tissue discarded during surgery) and biomaterials are used to construct bioartificial organs. A bioartificial kidney, for example, is constructed from kidney cells that have been cleverly linked to a ′membrane, ′ a porous capillary built from artificial polymer fibre. When human plasma is pushed via this tube, it reaches the kidney cells, which detect and eliminate toxins. In vitro, this bioartificial kidney can filter and cleanse blood, simulating the function of a real, healthy kidney. Future research will move away from the trial-and-error approach to implant optimization and toward the rational manufacturing of precisely formed nano biological devices.
Title : Side effect free cancer chemotherapy by directed gene delivery using nanomaterials
A C Matin, Stanford University School of Medicine, United States
Title : Artificial intelligence (AI) in biomedical engineering
Hossein Hosseinkhani, Innovation Center for Advanced Technology, Matrix HT, United States
Title : Novel gene therapy options for pulmonary hypertension
Yong Xiao Wang, Albany Medical College, United States
Title : 30,000 nano implants in humans with no infections, no loosening, and no failures
Thomas J Webster, Hebei University of Technology, China
Title : Challenges in skeletal tissue engineering
Patrizia Ferretti, UCL Great Ormond Street Institute of Child Health, United Kingdom
Title : Electroactive polymer-based smart scaffolds for tissue engineering and regenerative medicine
Federico Carpi, University of Florence, Italy