Cell encapsulation is a process in which living cells are encapsulated in selectively permeable polymeric materials (membranes/beads), making them a potential treatment for diseases like haemophilia, Parkinson's disease, lysosomal storage disorder (LSD), cancer, and diabetes. The encapsulated cells become immune, which means that the host's immune system is unable to recognize them and hence does not mount an immunological reaction against them. In tissue engineering applications, cell encapsulation could be a remedy to transplant rejection. Immobilization of cells within a polymeric semi-permeable membrane is the goal of cell microencapsulation technology. It allows for the bidirectional diffusion of molecules required for cell metabolism, such as oxygen, nutrients, growth factors, and other growth factors, as well as the outward diffusion of waste products and therapeutic proteins. At the same time, the membrane's semi-permeable nature prevents immune cells and antibodies from attacking the encapsulated cells, which they consider as foreign intruders, due to their semi-permeable nature. After an organ transplant, cell encapsulation may lessen the requirement for long-term immunosuppressive medicines to control side effects.
Title : Eliminating implants infections with nanomedicine: Human results
Thomas J Webster, Interstellar Therapeutics, United States
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Nagy Habib, Imperial College London, United Kingdom
Title : Graphene, butterfly structures, and stem cells: A revolution in surgical implants
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, London NW1 0NH, United Kingdom
Title : Precision in cartilage repair: Breakthroughs in biofabrication process optimization
Pedro Morouco, Polytechnic of Leiria, Portugal
Title : Keratin-TMAO wound dressing promote tissue recovery in diabetic rats via activation of M2 macrophages
Marek Konop, Medical University of Warsaw, Poland
Title : Assessing geometric simplifications in vertebral modeling for reliable numerical analysis of intervertebral discs
Oleg Ardatov, Vilnius University, Lithuania