Due to their limited ability to self-repair, the regeneration of injured tendons is a major challenge in orthopaedics. Tissue engineering has become a popular therapy option for tendons that have been injured. To manufacture cell-laden tissue constructions for implantation, the traditional tissue engineering technique depends on the utilization of culture-expanded patient's own cells and natural and/or synthetic biomaterial scaffolds. This strategy, however, has significant drawbacks, including donor-tissue morbidity, the requirement for a large number of immune-acceptable cells, the protracted in vitro production cycle of designed tissues, and the difficulty associated with long-term storage and preservation of created tissues. The practical deployment of engineered tendon constructs to treat injured tendons using the traditional tissue engineering technique has been hampered by these drawbacks. One of the emerging options is chemical modification of polymeric scaffold surfaces, which allows for improved biocompatibility while also serving as a protein delivery vehicle. Physical adsorption, radiation-mediated modifications, grafting, and protein modifications are all examples of successful strategies for changing the surface properties of polymeric scaffolds.
Title : A revolution or surrender: The success and failures of tissue engineering and regenerative medicine
Thomas J Webster, Hebei University of Technology, United States
Title : Efficacy and safety outcomes in patients with chronic traumatic brain injury: Final analysis of the randomized, double-blind, surgical sham-controlled phase 2 STEMTRA trial
Bijan Nejadnik, SanBio, Inc, United States
Title : Light-based bioprinting: From bioink design to modulation of cell response in bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
Title : Embracing the potential of biopolymer based hydrogel: The new frontier in chronic wound therapy
Madhu Gupta, School of Pharmaceutical Sciences, India
Title : A 3D -bioprinted in vitro adipose tissue model for the study of macrophage polarisation and function within metabolic disease.
Tiah Oates, University of Bristol, United Kingdom