Eye Tissue Engineering represents a cutting-edge field that seeks to address vision-related disorders and injuries through innovative biological approaches. Researchers in this field aim to develop functional and biocompatible substitutes for damaged ocular tissues, such as the cornea, retina, and lens. Scaffold-based strategies utilizing biodegradable materials provide a framework for cell attachment, proliferation, and differentiation, fostering the regeneration of damaged tissues. Stem cells, both embryonic and induced pluripotent stem cells, play a pivotal role in generating specialized cell types for ocular tissue reconstruction. Biomimetic materials, mimicking the extracellular matrix of native eye tissues, enhance integration and functionality. Advanced technologies, including 3D bioprinting, enable precise fabrication of complex ocular structures. Researchers are exploring the incorporation of bioactive factors and gene therapy to promote tissue regeneration and modulate immune responses. Successful outcomes in preclinical models fuel optimism for clinical applications, offering potential solutions for corneal blindness, retinal degeneration, and other vision impairments. However, challenges remain, such as achieving optimal functionality, long-term stability, and regulatory approval. Eye tissue engineering holds promise in revolutionizing ophthalmic care, offering hope for restoring vision and improving the quality of life for individuals affected by various ocular conditions.
Title : AI-integrated high-throughput tissue-chip for space-based biomanufacturing applications
Kunal Mitra, Florida Tech, United States
Title : Will be updated soon...
Vasiliki E Kalodimou, European University-Cyprus Ltd, Cyprus
Title : Will be updated soon...
Nagy Habib, Imperial College London, United Kingdom
Title : Will be updated soon...
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, United Kingdom
Title : Advanced 3D tissue models: Pioneering tools for investigating health and disease
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Title : Developing iPSC-derived 3D Outer Blood-Retinal Barrier Disease Models of Choroideremia for Gene Therapy Evaluation
Aradhana Kasimsetty, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), United States