Foveolar Cells

Foveolar Cells are specialized epithelial cells found in the lining of the stomach, particularly in the gastric mucosa of the gastric pits and foveolae. These cells play a crucial role in the protective function of the stomach lining. Foveolar cells are characterized by their tall, columnar shape and the presence of abundant mucous granules. They are responsible for secreting mucus, a viscous and slippery substance that forms a protective barrier on the surface of the gastric mucosa. This mucous layer helps shield the stomach lining from the corrosive effects of gastric acid, preventing damage to the underlying tissues. Additionally, foveolar cells contribute to the regulation of the stomach's microenvironment by producing bicarbonate ions, which further neutralize acidic conditions. The orchestrated activity of foveolar cells is essential for maintaining the integrity of the gastric mucosal barrier and preventing conditions such as gastric ulcers. Researchers continue to explore the intricate mechanisms underlying the function of foveolar cells to gain insights into gastric physiology and potential therapeutic strategies for gastric disorders.