Neurogenesis refers to the process by which new neurons, the basic building blocks of the nervous system, are generated from neural stem cells or progenitor cells. While traditionally believed to occur primarily during embryonic development, contemporary research has demonstrated that neurogenesis persists throughout adulthood, particularly in specific regions of the brain, such as the hippocampus and the olfactory bulb. In the adult brain, neural stem cells located in specialized niches undergo division and differentiation, giving rise to new neurons. This phenomenon is associated with cognitive functions, learning, and memory. Neurotrophic factors, environmental stimuli, and physical activity have been identified as factors influencing the rate of neurogenesis. Understanding neurogenesis is crucial for unraveling the complexities of brain plasticity, adaptation, and repair. It has implications for cognitive health, mood regulation, and recovery from neurological injuries or diseases. Conversely, deficits in neurogenesis have been linked to various psychiatric and neurodegenerative disorders. Research in neurogenesis encompasses molecular, cellular, and behavioral aspects. Advanced imaging techniques, molecular biology tools, and animal models are employed to explore the mechanisms underlying the birth, migration, and integration of new neurons into existing neural circuits. Manipulating neurogenesis holds therapeutic potential for conditions like depression, anxiety, and neurodegenerative diseases. While challenges remain in fully harnessing the regenerative capacity of the adult brain, ongoing studies continue to shed light on the intricacies of neurogenesis, offering hope for innovative treatments and interventions in neurological and psychiatric disorders.
Title : AI-integrated high-throughput tissue-chip for space-based biomanufacturing applications
Kunal Mitra, Florida Tech, United States
Title : Will be updated soon...
Vasiliki E Kalodimou, European University-Cyprus Ltd, Cyprus
Title : Will be updated soon...
Nagy Habib, Imperial College London, United Kingdom
Title : Will be updated soon...
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, United Kingdom
Title : Advanced 3D tissue models: Pioneering tools for investigating health and disease
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Title : Developing iPSC-derived 3D Outer Blood-Retinal Barrier Disease Models of Choroideremia for Gene Therapy Evaluation
Aradhana Kasimsetty, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), United States