Scaffolds are made of biodegradable materials in tissue engineering to enable tissue growth, ECM elaboration, and the final maturation or conversion of the implanted construct into functional, native tissue. The remodelling process is dynamic and complex, reliant on factors such as the host implant location, inflammatory response, mechanical environment, and disease status, to name a few. Despite the complexity of the problem, scaffold design principles allow some general alternatives in terms of chemistry and processing to regulate degradation, provided there is enough in vivo data to guide such design improvements. Non-invasive and non-destructive imaging technologies to examine implants in situ in a timely manner are crucial with the rapid expansion of biomaterial discovery and associated efforts to bring such discoveries into the clinic. Structure, mechanical, and biological changes such as scaffold degradation, mechanical strength, cell infiltration, extracellular matrix creation, and vascularization, to mention a few, are all part of the essential multidimensional information. Ultrasound imaging can be an excellent tool for both preclinical and clinical applications due to its inherent advantages of non-invasiveness and non-destructiveness.
Title : Small activating RNA from concept to phase 2 clinical trials
Nagy Habib, MiNA Therapeutics Ltd, United Kingdom
Title : Mechanical modulation of cell response in 3D bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
Title : Electroactive polymer-based smart scaffolds for tissue engineering and regenerative medicine
Federico Carpi, University of Florence, Italy
Title : Graphene “Hastalex®”, butterfly, and stem cells are set to revolutionise the development of human organs.
Alexander Seifalian, NanoRegMed Ltd, BioScience Innovation Centre, United Kingdom
Title : Design of 3D bioengineered personalized scaffolds to potentiate bone ingrowth and angiogenic network for oral tissues reconstruction
Christiane Salgado , Institute of Research and Innovation in Health(i3S), Brazil
Title : RADA16-I based scaffolds for wound healing and regenerative medicine
Deptula Milena, Medical University of Gdansk, Poland