Scaffolds are made of biodegradable materials in tissue engineering to enable tissue growth, ECM elaboration, and the final maturation or conversion of the implanted construct into functional, native tissue. The remodelling process is dynamic and complex, reliant on factors such as the host implant location, inflammatory response, mechanical environment, and disease status, to name a few. Despite the complexity of the problem, scaffold design principles allow some general alternatives in terms of chemistry and processing to regulate degradation, provided there is enough in vivo data to guide such design improvements. Non-invasive and non-destructive imaging technologies to examine implants in situ in a timely manner are crucial with the rapid expansion of biomaterial discovery and associated efforts to bring such discoveries into the clinic. Structure, mechanical, and biological changes such as scaffold degradation, mechanical strength, cell infiltration, extracellular matrix creation, and vascularization, to mention a few, are all part of the essential multidimensional information. Ultrasound imaging can be an excellent tool for both preclinical and clinical applications due to its inherent advantages of non-invasiveness and non-destructiveness.
Title : A revolution or surrender: The success and failures of tissue engineering and regenerative medicine
Thomas J Webster, Hebei University of Technology, United States
Title : Efficacy and safety outcomes in patients with chronic traumatic brain injury: Final analysis of the randomized, double-blind, surgical sham-controlled phase 2 STEMTRA trial
Bijan Nejadnik, SanBio, Inc, United States
Title : Light-based bioprinting: From bioink design to modulation of cell response in bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
Title : Embracing the potential of biopolymer based hydrogel: The new frontier in chronic wound therapy
Madhu Gupta, School of Pharmaceutical Sciences, India
Title : A 3D -bioprinted in vitro adipose tissue model for the study of macrophage polarisation and function within metabolic disease.
Tiah Oates, University of Bristol, United Kingdom