Preclinical animal testing is used to give reasonable data prior to early feasibility testing in people and human clinical trials in order to show that new technologies and therapies are safe and effective. During the nonclinical phase, animal models can help support and develop medical product development. Animal models that are well-designed can solve regulatory safety issues and provide further de-risking during product validation. Animal models can be used to evaluate minimum viable products and prototypes, which can help with quality assurance and compliance. To avoid superfluous preclinical research, a roadmap for product innovation strategies (regulatory, reimbursement) must be developed. Preclinical animal model safety and efficacy data are an important aspect of medical device development and are required to make these judgments. Before moving on to costly human trials, this can assist evaluate if the gadget is effectively tackling an actual need. Academic centers, which are generally based in linked veterinary medicine schools, provide unique resources that might help academic entrepreneurs fill this preclinical need.
Title : A revolution or surrender: The success and failures of tissue engineering and regenerative medicine
Thomas J Webster, Hebei University of Technology, United States
Title : Efficacy and safety outcomes in patients with chronic traumatic brain injury: Final analysis of the randomized, double-blind, surgical sham-controlled phase 2 STEMTRA trial
Bijan Nejadnik, SanBio, Inc, United States
Title : Light-based bioprinting: From bioink design to modulation of cell response in bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
Title : Embracing the potential of biopolymer based hydrogel: The new frontier in chronic wound therapy
Madhu Gupta, School of Pharmaceutical Sciences, India
Title : A 3D -bioprinted in vitro adipose tissue model for the study of macrophage polarisation and function within metabolic disease.
Tiah Oates, University of Bristol, United Kingdom