Growth factors (GFs), chemokines, cytokines, and other signaling molecules all play a role in wound healing and tissue regeneration. Numerous breakthroughs in the subject have shed light on the mechanics of wound healing, and different technical solutions have been proposed as a result of these scientific advances. However, the mechanisms of tissue regeneration following wound injury have yet to be fully understood. Current advancements in unique drug delivery systems (DDSs) that release growth factors (GFs) offer a huge opportunity to develop new medicines or improve the efficacy of existing treatments. These breakthroughs are especially important in the field of regenerative medicine, which is tackling challenges like wound healing and skin restoration. To this purpose, biocompatible biomaterials have been intensively investigated in order to improve DDS in vivo integration, increase the bioactivity of released medications, and deliver bioactive compounds in a targeted and regulated manner.