Repair, as opposed to regeneration, requires "patching" rather than "restoring" tissue components. The quantity of regeneration vs. repair that happens is determined by the cells' proliferative capacity, the stromal framework's integrity, and the duration of the damage and inflammatory response. Tissue repair (TR) is the process of a tissue's compensatory regeneration after a surgical, mechanical, or chemical insult, resulting in the tissue's structure and function being restored. The implementation of treatment models that have become an established part of everyday practice is enabled by current understanding of certain of the tissue repair mechanisms. Management of the inflammatory process, cell proliferation (excessive or defective), and extracellular matrix (ECM) remodelling are all part of the healing process. Repair, as opposed to regeneration, requires "patching" rather than "restoring" tissue components. The quantity of regeneration vs. repair that happens is determined by the cells' proliferative capacity, the stromal framework's integrity, and the duration of the damage and inflammatory response. Tissue repair is a dynamic process that prevents injury from progressing to organ failure and death. It is influenced by species, strain, age, and other individual features. Tissue repair has been shown to increase in a dose-dependent way until a dosage threshold is reached. Low to moderate doses accelerate tissue healing, but as the dose increases, the onset becomes more delayed. As a result, at doses above a specific threshold, the tissue healing response is both too small and too late to stop the injury from progressing.
Title : A revolution or surrender: The success and failures of tissue engineering and regenerative medicine
Thomas J Webster, Hebei University of Technology, United States
Title : Efficacy and safety outcomes in patients with chronic traumatic brain injury: Final analysis of the randomized, double-blind, surgical sham-controlled phase 2 STEMTRA trial
Bijan Nejadnik, SanBio, Inc, United States
Title : Light-based bioprinting: From bioink design to modulation of cell response in bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
Title : Embracing the potential of biopolymer based hydrogel: The new frontier in chronic wound therapy
Madhu Gupta, School of Pharmaceutical Sciences, India
Title : A 3D -bioprinted in vitro adipose tissue model for the study of macrophage polarisation and function within metabolic disease.
Tiah Oates, University of Bristol, United Kingdom