Cell therapy (also known as cellular therapy, cell transplantation, or cytotherapy) is a treatment in which living cells are injected, grafted, or implanted into a patient to achieve a therapeutic effect, such as by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity during immunotherapy or grafting stem cells to regenerate diseased tissues. Scientists experimented with injecting animal material in an attempt to prevent and treat illness in the eighteenth century, and cell therapy was established. Despite the fact that such efforts yielded no positive results, further research discovered in the mid-twentieth century that human cells could be used to help prevent the human body from rejecting transplanted organs, eventually leading to successful bone marrow transplantation, which has since become standard treatment for patients with compromised bone marrow due to disease, infection, radiation, or chemotherapy.