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2nd Edition of International Summit on Hematology and Blood Disorders

June 05-07, 2025

June 05 -07, 2025 | Rome, Italy

Platelets, Coagulation and Intrinsic Factors

Platelets, Coagulation and Intrinsic Factors

Platelets are little blood cells that assist your body stop bleeding by forming clots. When a blood artery in your body is injured, it sends signals to your platelets. Platelets rush to the damaged area and form a plug (clot) to stop the bleeding. Adhesion is the process of a substance spreading across the surface of a damaged blood vessel to halt bleeding. This is because platelets develop sticky tentacles that help them stick (adhere) to one another when they reach the injury site. Chemical signals are also sent out to recruit additional platelets. Aggregation is the process through which more platelets build up on the clot.

Coagulation, also known as clotting, is the transformation of blood from a liquid to a gel, resulting in the formation of a blood clot. It could lead to haemostasis, or the halt of blood loss from a damaged vessel, and then repair. Coagulation is caused by platelet activation, adhesion, and aggregation, as well as fibrin deposition and maturation. After a damage to the endothelium lining a blood artery, coagulation begins nearly immediately. When blood is exposed to the subendothelial space, two processes occur: platelet modifications and the exposure of subendothelial tissue factor to plasma factor VII, which results in the creation of cross-linked fibrin.

Coagulation is the process of forming a blood clot, which is necessary for haemostasis. The body's physiological response to injured blood arteries is haemostasis, which lowers, minimises, and eventually stops bleeding. The creation of a blood clot is characterised by a series of processes known as the coagulation process. Clotting factors are proteins that start processes that trigger other clotting factors. This happens through two routes that come together downstream to establish a single pathway that facilitates haemostasis.

Committee Members
Speaker at International Summit on Hematology and Blood Disorders 2025 - Jie Xu

Jie Xu

The University of Texas MD Anderson Cancer Center, United States
Speaker at International Summit on Hematology and Blood Disorders 2025 - Ravishankar Rao Baikady

Ravishankar Rao Baikady

The Royal Marsden NHS Foundation Trust, United Kingdom
Speaker at International Summit on Hematology and Blood Disorders 2025 - Peter J Van Der Spek

Peter J Van Der Spek

Erasmus University Medical Center, Netherlands
Hematology 2025 Speakers
Speaker at International Summit on Hematology and Blood Disorders 2025 - Aida I Richardson

Aida I Richardson

Ann & Robert H. Lurie Children's Hospital of Chicago, United States
Speaker at International Summit on Hematology and Blood Disorders 2025 - Maryam Asif

Maryam Asif

University of Washington, United States
Speaker at International Summit on Hematology and Blood Disorders 2025 - Raykina Elena

Raykina Elena

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Russian Federation
Speaker at International Summit on Hematology and Blood Disorders 2025 - Santosh Kumar Mondal

Santosh Kumar Mondal

Department of Pathology and Laboratory Medicine AIIMS, India
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