HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.

International Summit on Hematology and Blood Disorders

April 27-29, 2023 | Orlando, USA

April 27 -29, 2023 | Orlando, Florida, USA

Clonal Tracking & Gene Therapy

Clonal Tracking & Gene Therapy

CHIP stands for clonal hematopoiesis of undetermined potential, which occurs when hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the creation of a genetically unique subset of blood cells. This blood subpopulation is defined by a shared unique mutation in the cells' DNA, as the name implies; it is assumed that this subpopulation is "clonally" produced from a single founding cell and hence consists of genetic "clones" of the founder. When a stem or progenitor cell develops one or more somatic mutations that give it a competitive advantage in hematopoiesis over stem/progenitor cells without these mutations, a clonal population can form. Clonal hematopoiesis can also occur without a driving mutation, thanks to factors like neutral drift in the stem cell population. Clonal hematopoiesis can happen in healthy persons, but it's also been shown in patients with hematologic disorders. The size of the clonal population varies depending on the person; it can be as small as 2% of the blood or as much as 100%.

Gene therapy is a branch of medicine that focuses on genetically altering cells to provide a therapeutic effect or heal disease by repairing or reconstructing damaged genetic material. Gene therapy is based on the idea of correcting a genetic disease at its source. If, for example, a mutation in a gene results in the creation of a malfunctioning protein that causes a hereditary disease (typically recessively), gene therapy could be used to deliver a copy of the gene that does not include the detrimental mutation and thus creates a functional protein.

Committee Members
Speaker at Hematology and Blood Disorders 2023 - SSR Kumar Challa

SSR Kumar Challa

Xheme, Inc, United States
Speaker at Hematology and Blood Disorders 2023 - Mohamed Alsharedi

Mohamed Alsharedi

Markey Cancer Center at Lexington Clinic, United States
Speaker at Hematology and Blood Disorders 2023 - Stefan Gluck

Stefan Gluck

Global Medical Affairs at Celgene Corporation, United States
Hematology 2023 Speakers
Speaker at Hematology and Blood Disorders 2023 - Hamed Bazrafshan

Hamed Bazrafshan

Shiraz University of Medical Sciences, Iran (Islamic Republic of)
Speaker at Hematology and Blood Disorders 2023 - Jean Mercier Ythier

Jean Mercier Ythier

University of Paris-Panthéon-Assas, France
Speaker at Hematology and Blood Disorders 2023 - Erin Weigel

Erin Weigel

Kedrion Biopharma, United States
Speaker at Hematology and Blood Disorders 2023 - Noha Hassan Mahboub

Noha Hassan Mahboub

Cairo University, Egypt

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