This paper is based on the author’s personal history. It references various studies supporting her arguments on the depth and scale of individual and social problems and diseases of civilization in the modern world. Her descriptions and explanations have become a basis of n [....] » Read More
The weather has been thought to influence health for millennia: Hippocrates in his work “On airs, waters and places”, explicitly described potential pathologies related to microclimatic and climatic variations. Christopher Wild coined the term “exposome” i [....] » Read More
Since the emergence of the Corona virus in China at the end of 2019, it has swept the world until it posed an unprecedented health challenge. Millions of people around the world have become infected and many have lost their lives. From here, doctors began to consider available dr [....] » Read More
Background and objectives: The association between obesity and diabetic nephropathy (DN) has been studied but the results of these epidemiological studies are not entirely consistent. The causal effect of body mass index (BMI) on DN and kidney traits was evaluated by the individu [....] » Read More
Amide proton transfer (APT) imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. APT imaging is a specific type of chemical exchange saturation transfer imaging. Theoretically, the APT-MRI signal depends primari [....] » Read More
Atrial fibrillation (AF) is a type of cardiac arrhythmia associated with major adverse events, like hospitalizations and death. Tools and techniques for the prediction of AF are required to identify high-risk individuals. Currently, the most used tool to this aim is the CHARGE- [....] » Read More
The CYP2D6 gene (22q13.2) encodes the CYP2D6 protein that localises to the endoplasmic reticulum, and is highly expressed in liver, brain, intestinal tissue and lymphoid cells; it comprises only 2–4% part of total hepatic CYP content but is a main drug-metabolising enzyme r [....] » Read More
Objective: To perform molecular docking to determine the binding interactions of vitamin C and vitamin D with druggable targets on SARS-CoV-2. Methods: We have retrieved two vitamins: vitamin C and vitamin D (as the ligand molecules) from https://pubchem.ncbi.nlm.nih.gov/, and [....] » Read More
Clinical data is the most valuable and sensitive asset about humans. While there are a variety of effective policies, processes, and regulations in place to secure patient information, privacy and security vulnerabilities in electronic health record (EHR) systems remain major c [....] » Read More
Perinatal hypoxic-ischemic brain injury is a major cause of neonatal death and long-term disability. Approximately 15–25% of newborns with hypoxic-ischemic encephalopathy (HIE) die during the postnatal period, and surviving infants are at risk for the development of se [....] » Read More
Barrett esophagus (BE) is a pre-malignant condition characterized by the conversion of the normal esophageal squamous epithelium into metaplastic columnar epithelium. BE is the only known precursor lesion of esophageal adenocarcinoma (EAC), a cancer with high mortality rate (80% [....] » Read More
Chloroquine represents at least a basic prototype antimalarial drug, widely applied in several branches of medicine and also recently against a new zoonotic origin coronavirus. At present, there is little awareness of chloroquine's psychiatric side effects, which appear to be [....] » Read More
Inborn errors of metabolism are numerous and have a great variety of presentation; Genetic testing can help reach a diagnosis faster and Identifying treatment options. Exome or genome sequencing was useful in such cases. This presentation is to provide an idea of our experienc [....] » Read More
Title : Precision Pharmacotherapy in the Treatment of Epilepsy - Use of Antiseizure Medications and Therapeutic Blood Level Monitoring
Roy Gary Beran, University of New South Wales, Australia
All too often patients, known to have epilepsy, attend the Accident and Emergency Department (A&ED) following an epileptic seizure and, before a proper history or examination has occurred, the patient is loaded with an antiseizure medication (ASM), other than that which they [....] » Read More
Title : Antibody-Proteases as translational tools of the newest generation to be applied for biodesign and bioengineering to get Precision and Personalized healthcare services Re-armed
Sergey Suchkov, A.I. Evdokimov MGMSU, Russian Federation
Catalytic Abs (catAbs) are multivalent immunoglobulins (Igs) with a capacity to hydrolyze the antigenic (Ag) substrate. In this sense, proteolytic Abs (Ab-proteases) represent Abs to provide proteolytic effects. Abs against myelin basic protein/MBP with proteolytic activity ex [....] » Read More
Title : Precision Diagnostics and Medical Devices: Innovative Imaging Technologies for Lung Cancer Screening in Large Populations
Huiqin Yang, ICON Clinical Research Ltd, United Kingdom
Precision diagnosis is an essential part of precision medicine. Diagnosis of lung cancer frequently occurs in its later disease stage. It is important to note that the prognosis for long-term survival with lung cancer is very poor. Early detection of lung cancers may lead to an i [....] » Read More
Title : Use of indocyanine green fluorescence imaging in the extrahepatic biliary tract surgery
Orestis Ioannidis, Aristotle University of Thessaloniki, Greece
Cholelithiasis presents in approximately 20 % of the total population, ranging between 10% and 30 %. It presents one of the most common causes for non malignant surgical treatment. The cornerstone therapy is laparoscopic cholecystectomy, urgent of elective. Laparoscopic cholecyst [....] » Read More
Title : Methylating Agents as Rescue Adjunct Therapy to Chemotherapeutic Alkylating Medications for Improved Outcomes in Chronic Lymphocytic Leukemia: A Case Study and Protocol with National Implications
Bruce K Kowiatek, Blue Ridge Community and Technical College, United States
Although the non-enzymatic methylation of cytidine (C) by S-adenosylmethionine (SAM) and methylcobalamin to 5-methylcytidine and its subsequent spontaneous deamination to thymidine (T) in DNA at physiologic pH and temperature has been implicated in some C to T point mutagen [....] » Read More
Title : Telomere in health and disease
Lu Xu, Hangzhou Normal University, China
The aging of the population is a major global social problem. The fundamental problem of population aging is the substantial increase in the aging population and aging-related diseases, but there is still a lack of scientific and reliable disease risk predictors. How to prevent a [....] » Read More
Title : Smartphone mental health interventions for anxiety and depression
Doaa Alamoudi, University of Bristol, United Kingdom
Background: Anxiety and depression are common (prevalence of 18% to 21%) in UK young people [1]. Insomnia (difficulty sleeping, staying asleep) is associated with the onset of mental health problems [2]. Automated insomnia treatment is effective for mental health symptoms. The on [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up to secure the human healthcare, wellness and biosafety through the view of public health
Sergey Suchkov, A.I. Evdokimov MGMSU, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recog [....] » Read More
Title : When the Numbers Lie
Xu Chen, The College of St. Scholastica, United States
Xu Chen has a Bachelor’s of Art degree in Biology from The College of St. Scholastica. That was her first 4-year degree in her life. After that she went to nursing school for couple years. Then she went back to the College of St. Scholastica to get a Master’s of Scien [....] » Read More
Title : Genetic and transcriptional alterations during targeted therapy of advanced human lung cancer revealed by single-cell RNA omics
Wei Wu, UCSF, United States
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was performed using 49 clinical biopsies obtaine [....] » Read More
Title : Circulating Coding and Long Non-Coding RNAs as Potential Biomarkers of Idiopathic Pulmonary Fibrosis
Stefania Di Mauro, University of Catania, Italy
Background: Idiopathic Pulmonary Fibrosis (IPF) is a chronic degenerative disease with a median survival of 2-5 years after diagnosis. Therefore, IPF patient identification represents an important and challenging clinical issue. Current research is still searching for novel rel [....] » Read More
Title : Impact of interprofessional learning on professional dynamics among healthcare professionals
Chukwuemeka Henry Elugwu, Alliance Medical Limited, United Kingdom
Assessment of the impact of interprofessional learning (IPL) on professional dynamics among radiographers and other healthcare professionals is very important for quality patient care management. The research design was a prospective cross-sectional descriptive study. It was cond [....] » Read More
Title : Revisiting ayurvedic medicinal plants for their antiviral properties
Sunita Singh, Navyug kanya Mahavidyalaya , India
Traditional herbs provide enormous scope to for the identification of viable alternatives against viral diseases. This presentation will describe various ayurvedic herbs that have antiviral properties and provide a useful literature review on their antiviral properties along with [....] » Read More
Title : Transcription factor 4 expression in gallbladder cancer
Kaushik Neogi, Banaras Hindu University, India
Dysregulation of β-catenin/TCF4 interaction in Wnt/β-catenin signaling plays a critical role in gastrointestinal cancers. Interaction of β-catenin with T-cell factor-4 (TCF4) is a key step in the activation of Wnt genes. The Expression of TCF4 was performed by reve [....] » Read More
Title : Vaccine’s boosting issues to the biochemistry point of view
Dessalegn Temesgen Leye, Addis Ababa Science & Technology University, Ethiopia
Next to main prophylaxis measures that must be taken to avoid getting contagion, vaccination can be the second option to minimize the infection’s severity within the body and may help to shorten the transmitting durability of some types of pathogens. Vaccination in its turn [....] » Read More