Introduction: Mantle cell lymphoma is a rare subtype of non-Hodgkin’s lymphoma, which may develop into other subtypes, such as diffuse large B-cell lymphoma, which is the most common among all non-Hodgkin's lymphomas. Usual clinical features of diffuse large B-cell [....] » Read More
Introduction. ABO blood group antigens are related with pandemics of infectious diseases. The specific distribution of blood group antigens in the world is the result of the selectivity of Natural Selection. The several studies suggested also the possible link with &n [....] » Read More
Introduction: The current treatment of Sickle Cell Disease includes hydroxyurea and RBC transfusions or exchange transfusions. RBC exchange is the replacement of a patient’s RBC with donor RBC and can be performed either manually or automated. Automated RBC exchange is [....] » Read More
In the current digital world, hash may consider as a footprint or fingerprint of any digital term but from ancient era human fingerprint considered as the most trustworthy criteria for identification. The fingerprint of a human cannot be change with time even up to death of an in [....] » Read More
Diagnosis and treatment of inherited bleeding disorders in children secondary to deficiency in single or multiple coagulation factor is of great importance and represent a challenging issue in developing country like Jordan. The prevalence of bleeding disorders varies in differen [....] » Read More
Background: Iron deficiency anaemia is the burning health issue of adults as well as children in India, which is evaluated by deficiency in serum ferritin level, mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). DMT1 mutations primarily affect iron ut [....] » Read More
Coronavirus disease 19 (COVID-19) pandemic which is caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global threat to humanity and has become challenging even for the most durable healthcare systems. In this moment of misery and lack of control [....] » Read More
Blood banking brings the potentially life-saving benefits to the patients who require transfusion. Transfusion medicine has undergone advancements such as component therapy, where cellular components including, packed erythrocytes & platelet concentrates are transfused. Eryth [....] » Read More
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western World. Therapeutic options have changed dramatically over the last decade, from ineffective chemotherapy to highly specific small molecules that target crucial pathways in CLL cells. The first available [....] » Read More
Anemia is a common blood disorder that affects an estimated 1.62 billion people worldwide, which is approximately 24.8% of the global population. Women and children are particularly vulnerable to anemia, with an estimated 29% of non-pregnant women, 38% of pregnant women, and 47% [....] » Read More
Proteins denaturation is a phenomenon that can be due to some diseases or external stresses. In particular, hemoglobin can be subjected to denaturation (unfolding) of its secondary structure due to various causes, that is represented by a decrease in intensity of the α-heli [....] » Read More
Heparin-induced thrombocytopenia (HIT) is a prothrombotic autoimmune disorder confirmed by the existence of Heparin-Platelet Factor 4 (HPF4) antibodies. The aim of this work is to study the possible relationship between anti-HPF4 and antiphospholipid antibodies (aPLs) that may ex [....] » Read More
Thromboembolism seems to be a challenging problem globally in coronavirus disease-2019 (COVID-19). Hypercoagulable states with unusual higher tendency for thrombotic events were described among severe and critically ill patients with COVID-19 infection with lower survival rates. [....] » Read More
COVID-19-related symptoms, risk factors for thrombosis, coagulation, and inflammatory parameters were compared in 145 previously healthy non-critically ill young adults, with 29 patients reporting uncommon thrombotic-events (UTEs) and 116 not experiencing thrombotic-events. In UT [....] » Read More
Hepatic veno-occlusive disease (VOD) / sinusoidal obstruction syndrome (SOS) is a mortal disease being seen in Hematopoietic Stem Cell Transplantation (HSCT). It was seen in almost 14% of all HSCT cases (adult and pediatric) and 30% in pediatric patients. Whereas anicteric VOD wa [....] » Read More
Thalassemia is a hereditary disease due to defective globin chain production. This defective globin become the cause of accumulation of excessive globin (unbound) in the erythrocytes and ultimately lead to the ineffective erythropoiesis. Despite the modern technologies, there is [....] » Read More
Background: Identifying and understanding the factor that influence health-related quality of life (HRQOL) in patients with leukemia is critical to creating more appropriate clinical, counseling, and social support programs to develop treatment results for these [....] » Read More
Sickle Cell Anemia is an increasing global health genetic problem characterized by chronic hemolytic anemia and tissue damage due to repeated microvascular obstruction by sickle shaped cells. Estimations suggest increasing number of infants born with Sickle Cell Anemia by year [....] » Read More
Aim: This retrospective study aimed to evaluate the efficacy and safety of adopting the pediatric-inspired ALL chemotherapy protocol in treating AYA patients diagnosed with ALL and to compare the clinical outcome with other adult ALL chemotherapy Protocol. Methods: T [....] » Read More
Background: Multiple myeloma (MM) is a disease characterized by heterogeneous clinical presentations as well as complex genetic and molecular abnormalities. In MM, cytogenetic analysis is a challenge because of the low proliferation of malignant plasma cells. Thus, interphase flu [....] » Read More
In pregnancy, anaemia is when haemoglobin concentration is less than 11 g/dL in the first and the third trimester or a haemoglobin concentration of less than 10.5 g/dL in the second trimester. Globally, anaemia is a public health problem since ancient years. During pregnancy, era [....] » Read More
Background:Myocardial Ischaemia (MI) in children living with sickle cell anaemia (SCA) is rarely reported, especially in low- and middle-income countries like Nigeria. The occurrence of MI among children living with this disease could portend untoward outcomes on their quality of [....] » Read More
Moya moya disease is a chronic cerebral vasculopathy first described in 1957. The disease is named after the appearance of collateral blood vessels that form following the gradual occlusion of arteries of the circle of Willis. The term Moya moya disease (MMD) is used for the dise [....] » Read More
Introduction:Coronavirus disease 2019 also known as COVID-19 is caused by SARS-CoV-2 virus. The disease's symptoms range from asymptomatic to inflammatory cytokine form involving multiple organs. Hematological complications of COVID-19 include cytopenia, coagulation abnormali [....] » Read More
Coronavirus disease 2019 (COVID-19) has shown high incidences of thrombosIs, especially pulmonary embolism. Superior Vena Cava Syndrome (SVCS) can be caused by external compression by tumors or intrinsic thrombosis. Here, we report a rare case of SVC thrombosis with a history of [....] » Read More
Introduction/background: Any discrepancies of Factor VII (FVII) activity levels using different thromboplastin in a prolonged Prothrombin Time (PT), suspect FVII Padua. This case presented with PT discrepancies using different thromboplastins, FVII Padua is highly suspected. [....] » Read More
Hyperviscosity syndrome (HVS) is an emergent complication of Waldenstrom’s Macroglobulinemia (WM) characterized by neurological, visual, and auditory impairment. Only few cases of HVS with bilateral visual and auditory impairment have been reported in the literature. We rep [....] » Read More
Introduction: While new approaches in treatment have improved diagnosis and management of sickle cell disease (SCD) over the last few decades, many patients still have severe complications leading to repeat ED visits and hospitalizations. Better risk stratification can help to re [....] » Read More
Introduction: Osteonecrosis is one of the most common musculoskeletal complications in sickle cell disease, which is a prevalent and particularly debilitating disorder in this population. Several studies have shown the relevance of brain-derived neurotrophic factor (BDNF) as [....] » Read More
Back ground: Functional capacity is an individual’s ability to perform daily activities related to the participation in the community. Beta-thalassemia is a blood disorder characterized by decreased production of hemoglobin which may in turn results in anemia in earl [....] » Read More
Background: Serum iron levels vary throughout the day, morning samples were assumed to be higher than afternoon or evening levels. This descriptive observational case study was conducted during June to August 2013 in Khartoum state to determine the diurnal variation of serum iron [....] » Read More
Title : Hereditary hemolytic anemias due to red blood cell membranopathies rheological and genetic approach
Joan Lluis Vives Corrons, Institute for Leukaemia Research Josep Carreras, Spain
Hereditary red blood cell (RBC) membranopathies are characterized by mutations in genes encoding skeletal/lipid bilayer proteins that alter the membrane complex structure. Hereditary spherocytosis (HS) is the most common inherited RBC membranopathy, leading to hereditary hemolyti [....] » Read More
Title : Improving outcomes of curable lymphoma in resource constrained regions
Reena Nair, TATA Medical Centre, India
Despite a low incidence of lymphoma, mortality remains high in Low/Medium HDI countries [1, 2]. The possible reasons include – limited access to tertiary cancer or specialized centres, and lack of trained pathologists [3]. Patients present with advanced stage dis [....] » Read More
Title : Managing bacterial eradication in disease and survival for life support systems on earth and space
A C Matin, Stanford Medical School, United States
Bacteria like Escherichia coli cause disease but are also useful in resource regeneration. Its UPEC strain causes cystitis, which is treated by gentamicin. The protein Ys, encoded by the rpoS gene, controls E. coli resistance to antimicrobial agents. We discovered that rpoS delet [....] » Read More
Title : Immuno-oncology (IO): 2023 and beyond
Stefan Gluck, Global Medical Affairs at Celgene Corporation, United States
The idea of using the immune system to fight cancer is over 100 years old. (Paul Ehrlich’s “Magic Bullet”). A new molecular approach over the last decade or so, led to a better understanding of the immune system. Our focus became the T cell, its development and [....] » Read More
Title : PD-L1 Expression in anaplastic large cell lymphoma
Jie Xu, The University of Texas MD Anderson Cancer Center, United States
The programmed cell death 1 (PD-1) pathway is a recently recognized mechanism of tumor immune evasion. In our study, programmed cell death ligand 1 (PD-L1) expression was evaluated in patients with systemic anaplastic large cell lymphoma: including ALK+ and ALK-negative cas [....] » Read More
Title : The complete evidence that starling’s law responsible for many errors and misconceptions on fluid therapy in shock is wrong: The correct replacement is the hydrodynamic phenomenon of the porous orifice (G) tube
Ahmed N Ghanem, Mansoura University, Egypt
Introduction and objective: To report the hydrodynamic of a porous orifice (G) tube as replacement for the wrong Starling’s law. Material and methods: Hydrodynamics of the G tube, based on capillary ultra-structure, were studied. The effect of changing G tube o [....] » Read More
Title : Achieving 100% blood traceability compliance: A United Kingdom district hospital experience
Francis Ajeneye, Princess Alexandra Hospital NHS Trust, United Kingdom
The National blood transfusion center gives its utmost priority to safe blood transfusion and this is done through monitoring all the threats that can be transmitted through blood transfusion. Safe blood transfusion depends on efficient testing techniques for blood donors and an [....] » Read More
Title : LncRNA MALAT1, post-transcriptionally stabilized by NSUN2-mediated M5C modification, exerts properties in bone lesions formation in multiple myeloma
Xing Cui, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China
Multiple myeloma (MM) is still an incurable disease and osteoclast-mediated bone destruction is a hallmark. Existing agents effectively reduce the number of osteoclasts (OCs) and prevent bone-related diseases but have little effect on overall survival. Investigating the potential [....] » Read More
Title : Tyrosine kinase inhibitor treatment leads to complete response in three-way variant of philadelphia positive translocation (9;15;22)(q34;p11;q11) of chronic myeloid leukemia
Diwakar Sharma, All India Institute of Medical Sciences, India
Philadelphia (Ph) positive chromosome comprises 90-95% of chronic myeloid leukemia (CML). The remaining 5-10% consists of intricate translocations that may involve a third chromosome. The impact of Tyrosine kinase inhibitor (TKI) treatment on the variant Ph Chromosomes is not k [....] » Read More
Title : A study of hypercoagulable and inflammatory markers in Covid-19 patients
Ritu Sharma, Government Medical College, India
A procoagulant state and dysfunctional immune response prevails in SARS-Cov2 infection. The goal of the present study was to explore the trend of potential parameters such as D-Dimer, IL-6, C-reactive protein and Pro-calcitonin (PCT) in Covid-19 patients. The study was conducted [....] » Read More
Title : Trauma management in transfusion medicine
Francis Ajeneye, Princess Alexandra Hospital NHS Trust, United Kingdom
Trauma remains a leading cause of death in all ages. Haemorrhagic shock accounts for 80% of deaths in the operating theatre and up to 50% of deaths in the first 24 h after injury. Exsanguination is an important cause of mortality for trauma patients, and the successful management [....] » Read More
Title : Covid-19 microthrombosis in vivo assessed by conjunctival video capillaroscopy
Aristotle G Koutsiaris, University of Thessaly, Greece
Currently, more than 6.8 million deaths have been reported globally [WHO] from the COVID-19 pandemic and numerous symptoms have been observed in patients surviving COVID-19 which were described by the term “long COVID syndrome”. The injured endothelium has a primary r [....] » Read More
Title : Clinical use of cryopreserved platelets: The Czech republic concept
Milos Bohonek, Military University Hospital Prague, Czech Republic
The short shelf-life of fresh platelets (PLTs) limits their efficient inventory management and availability during a massive transfusion protocol. Risk of insufficient availability can be mitigated by building an inventory of cryopreserved platelets. Method: Platelets are froz [....] » Read More
Title : The contested market of plasma
Jean Mercier Ythier, University of Paris Pantheon Assas, France
Voluntary, anonymous free gift-giving has become nowadays the dominant norm for blood donation for transfusion purposes, in view of its established ability to satisfy the needs in labile blood products in satisfactory conditions of safety and cost. But the economy of blood produc [....] » Read More
Title : Can a prolonged aPTT predict a positive lupus anticoagulant in a patient with thrombosis?
Pranavi Sanka, Warren Alpert Medical School of Brown University, United States
Background: Antiphospholipid syndrome (APLS) is a hypercoagulable state characterized by thrombotic events (venous or arterial) or obstetric complications along with persistent positivity of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, or β2-glycoprotei [....] » Read More
Title : Volume Kinetic (VK) Shocks or Volumetric Overload Shocks (VOS) in clinical practice
Ahmed N Ghanem, Mansoura University, Egypt
Volume kinetic (VK) shocks are cardiovascular shocks induced by acute substantial volume changes of the cardiovascular system in either direction by decrease or increase. A decrease in cardiovascular volume induces the long established and well-known hypovolemic and haemorrhagic [....] » Read More
Title : Diagnosis and treatment for plasminogen deficiency type 1 (Plgd-1): An ultra-rare hematologic disorder
Erin Weigel, Kedrion Biopharma, United States
Plasminogen deficiency (PLGD) is an ultra-rare disorder, which is a subset of rare diseases that affect less than 1,000 individuals in a country. PLGD is classified as hypoplasminogenemia (PLGD-1) or dysplasminogenemia (PLGD-2). PLGD-2 is typically an asymptomatic qualitative dis [....] » Read More
Title : Peripheral hematological predictors of morphological remission/hemopoitic recovery in plasma cell disorders after induction chemotherapy
Hamzullah Khan, Nowshera Medical College, Pakistan
Objectives: to determine the predictive values of peripheral hematological markers for remission in cases of Plasma cell disorders/Multiple myeloma after induction therapy. Material and methods:This prospective study was conducted in the department of Hematology, MTI Hayatabad [....] » Read More
Title : Venous thromboembolism in a patient with vitamin B12 deficiency and probable Apla syndrome
Alex Chandy, Stoke Mandeville Hospital, United Kingdom
Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality. While early recognition of the condition is important, equally important is the identification of possible etiological factors. Each patient with venous thrombosis would have multiple factors resp [....] » Read More
Title : The burden of sickle cell in Uganda
Evelyn Harlow Mwesigwa, Uganda National Health Laboratory and Diagnostic Services Ministry of Health, Uganda
In Uganda, a plethora of a health priorities heavily weighted by infectious/communicable diseases which take precedence in resource allocation have left non-communicable diseases such as sickle cell anaemia largely under-studied. The sickle cell trait burden in the country was re [....] » Read More
Title : Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours
Michiko N Fukuda, Sanford-Buhnham-Prebys Medical Discovery Institute, United States
Annexin A1 is expressed specifically on the tumour vasculature surface. Intravenously injected IF7 peptide (IFLLWQR) targets tumour vasculature via annexin A1. We tested the hypothesis that IF7 overcomes the blood–brain barrier and that the intravenously injected IF7C(RR)-S [....] » Read More
Title : Curvularia and the brain: Case demonstration of optimal management
Brandon Lucke Wold, University of Florida, United States
Background: Curvularia is a ubiquitous fungus found in tropical climates and has been reported to grow on marijuana leaves. Rarely, it can infect humans and propagate from the nasal sinuses into the brain. Case: A 28-year-old immunocompetent patient presented with history of nas [....] » Read More
Title : AI and machine learning technologies on immunotherapy
Sanghoon Lee, Marshall University, United States
Cancers have long been investigated to be uncovered by differential microenvironmental conditions of malignant tumors for effective cancer diagnosis, prevention, and treatment. Recent advances in whole slide imaging technologies with ultra-high resolution have led to the accurate [....] » Read More
Title : High grade B-cell lymphoma with MYC, BCL2 w/wo BCL6 rearrangements
Shaoying Li, The University of Texas MD Anderson Cancer Center, United States
High grade B-cell lymphoma with MYC and BCL2 with or without BCL6 rearrangements is also called double/triple hit lymphoma (DHL). MYC and BCL6 rearrangements, the previous MYC and BCL6 DHL has been excluded from this category in the 5th WHO classification. In the past few years, [....] » Read More
Title : Using capillary whole blood to quantitatively measure ferritin: A validation trial of a point-of-care system
Joanna Fiddler, Clemson University, United States
Iron deficiency is a public health problem with devastating health, developmental and behavioral effects, often exacerbated due to affordability and access to screening and diagnosis. Using IronScan™ a portable, point-of-care diagnostic system capable of quantitatively meas [....] » Read More
Title : Deciphering the impact of bilf1, a new potential target therapy encoded by Epstein-Barr virus
Lucia Mundo, University of Limerick, Italy
Burkitt lymphoma (BL), which arise from germinal centre B cells (GCB), is an aggressive non Hodgkin B-cell lymphoma. The hallmark of nearly all BL tumours is the chromosomal translocation between the MYC gene and one of the immunoglobulins (Ig) heavy or light chain loci. In accor [....] » Read More