Jianhua Luo, University of Pittsburgh School of Medicine, United States
Chromosome mutations and rearrangements are some of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have identified a panel of fusion genes i [....] » Read More
Title : Towards early stage detection of ovarian cancer
Michael Thompson, University of Toronto, Canada
Ovarian cancer is the most deadly gynaecological disease that affects a quarter of a million women annually, resulting in over 140,000 deaths worldwide. Currently, detection of ovarian cancer requires time-consuming imaging techniques such as transvaginal ultrasound and MRI scans [....] » Read More
Title : Investigating adverse health risks from vaccine cell lines, adventitious contaminants and certain ingredients
Sherri J Tenpenny, Tenpenny Integrative Medical Center, United States
Vaccination is said to be a valuable public health tool for preventing infection. However, there are growing concerns over the increased number of reported severe side effects following vaccination. This presentation will discuss the use of immortalized cell lines, the presence o [....] » Read More
Title : Personalized oncologic medicine in children: Current status and future promises
Atif A Ahme, Children’s Mercy Hospitals and Clinics, United States
Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps into solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor’s variability in genes have provided greater understand [....] » Read More
Title : Metastatic breast cancer; Cure or remission with loco-regional treatment?
Atilla Soran, University of Pittsburgh Medical Center, United States
The incidence of de novo stage IV breast cancer (BC) is between 5 to 10% and, systemic therapy (ST) is the primary treatment choice. However, more and more studies show that ST may not be the only option. The traditional goal of loco-regional in such cases is to palliate symptoms [....] » Read More
Title : Breast cancer service of the future
Penny Kechagioglou, GenesisCare, United Kingdom
The Breast Service of the Future is a service transformation project, which aims at combining all elements of excellent cancer care from diagnosis to survivorship. At times of financial and workforce pressures, there should not be any compromise in the quality, efficiency and acc [....] » Read More
Title : It is about time: Wire-free localization of positive axillary lymph nodes prior to neoadjuvant therapy may offer an option to simplify and de-escalate axillary management
Mary K Hayes, Memorial Healthcare System, United States
Breast cancer conservative surgical treatment programs rely on the available image guidance devices and skills of the radiologist and surgeon team. Each breast cancer treatment team adopts the most effective localization and margin assessment technique based on the skills and tec [....] » Read More
Title : Massively parallel sequencing datasets for benchmarking virus integration tools
Luigi Marongiu, University of Heidelberg, Germany
Virus integration is increasingly indicated in the public domain as a major risk factor in carcinogenesis. Massively parallel sequencing (MPS) has become one of the most popular tools for the identification of viral genomes in human samples and several tools have been designed to [....] » Read More
Title : Ageism and simple mastectomy: Are we there yet?
Pasupathy Kiruparan, Blackpool Victoria Hospital, United Kingdom
Background: Age discrimination in the provision of health and care services was banned in the UK in 2012. However there continue to be age related discrepancies in the prevalence, treatment and outcomes experienced by people with breast cancer. British Association of Day Surgery [....] » Read More
Title : Window of opportunity clinical protocols in head and neck squamous cell cancer
Mercedes Porosnicu, Wake Forest University School of Medicine, United States
Head and neck squamous cell carcinoma (HNSCC) represents the 5th most common cancer in the world, characterized by poor prognosis. Significant recent therapeutic advances changed the HNSCC brand but superior survival is limited to a small percentage of patients. Promoting novel t [....] » Read More
Title : Utility of pap smears screening in the detection of cervical neoplasia
Saritha Karre, ESIC Medical College & Hospital, India
I will be discussing and describing on spectrum of lesions of cervical neoplasia and the utility of cervical cytopathology in detecting the premalignant and malignant lesions. Discussion on the risk of these lesions in different age groups, so that appropriate and preventive meas [....] » Read More
Title : : A novel chemopreventive strategy based on tumor suppressor micrornas produced in bioengineered edible plants
Vicki Vance, University of South Carolina, United States
MicroRNAs (miRNAs) are small noncoding RNAs that comprise an emerging class of therapeutic agents with significant potential for the prevention and treatment of many diseases, including cancer. Many different forms of cancer are associated with loss or reduced accumulation of one [....] » Read More
Title : Inverse microRNA signatures in alzheimers disease and cancer A diagnostic perspective
Urszula Wojda, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Poland
One of the major challenges in cancer and Alzheimer’s disease (AD) is identification of early, non-invasive biomarkers and elucidation of their functions. Circulating microRNAs (miRNAs) have been extensively studied as potential biomarkers for cancer and AD. Their profiles [....] » Read More
Title : Application of CTCs for biomarker development of immunotherapies
Zhenlong Ye, Shanghai Baize Medical Laboratory, China
I mmunotherapies with chimeric antigen receptor-modified T (CAR-T) cells and Immune Checkpoint Inhibitors (ICIs) have shown exhilarative clinical outcome in treating Cancers. When applying CAR-T-based and ICIs-based immunotherapies for treating solid tumors, detection of expressi [....] » Read More
Title : Novel proteomic changes in yeast mitochondria provide insights into mitochondrial functioning upon over-expression of human p53
Archana Kumari Redhu, Indian Institute of Technology, India
Cancer cells display enhanced glycolytic activity and impaired oxidative phosphorylation even in the presence of adequate oxygen (Warburg effect). Mitochondrial physiology is a promising hit target for anti-cancer therapy because of its key role in Warburg effect and activating a [....] » Read More
Title : Comparison between modified papanicolaou stain and hematoxylin eosin stain for staining keratin in oral tissue sections
Nusyba Mohamed Ahmed Bushra Mohamed Ahmed, University of Medical Sciences and Technology, Sudan
This presentation will discuss the aim of the study; to compare the staining specificity and intensity of Hematoxylin and Eosin (H&E) stain and Modified Papanicolaou stain, to stain the keratin present in Oral Squamous Cell Carcinoma. It will also discuss the methodology used [....] » Read More
Title : Clinical presentation, management and biomarkers of cytokine release syndrome after anti-CD19 cart-cell therapy for r/r ALL
Ping Li, Tongji University, China
Chimeric antigen receptor T (CAR-T) cell therapy has emerged as a novel treatment modality for B-cell malignancies. CD19-specific CAR-T cells induce high rates of initial response among patients with relapsed B-cell acute lymphoblastic leukemia (ALL). However, cytokine release sy [....] » Read More