Abstract:
Introduction:
Mutated bacteria and virus along with polluted air, water and food makes difficult for individual’s immune system to keep us health or recover faster. The hypothesis of meta medicine that most of diseases can be cured by our own immune fails. Thus, the need to support immune system is need of next generation. Mulmina® was developed as a palatable drink approved for used as an antioxidant, immunity booster and stress reliver in 2018. The two variant Mulmina® Mango and Mulmina® Amla orange is being used by various consultant across India and giving wonderful results in the patient.
Method:
Mulmina® Mango is elixir of Curcuma longa, Centella asiatica in Mango pulp enriched with various vitamin and minerals. Mulmina® Almla Orange contains Embolic officinalis and Citrus reticulata along with various vitamin and minerals. Safety and efficacy of Mulmina® was studied in various preclinical and clinical studies in different medical research institute. Immune busting activity, oxygen radical absorbance capacity (ORAC) evaluation, Antistress effect, Antiallergic activity and protective effect against chemotherapy was evaluated in preclinical studies. Mulmina® was also evaluated for is antioxidant, immune boosting, and Stress reliving property in various trial with different condition like pre-eclampsia, PCOS, infertility, viral infection, and post vaccination.
Result:
In pre-clinical studies Mulmina® exhibits a dose dependent immunomodulatory activity and reduce elevated level of cortisol in stressed mice which occurs because of stress related dysregulation of HPA axis. Mulmina® produced significant decrease in the TNF-α, a pro-inflammatory cytokine that plays role in the pathogenesis of stress-related disorders like anxiety and depression. Mulmina® stabilizes mast cell degranulation induced by compound 40/80. Mulmina® increases immunity by reducing elevated level of milk induced leucocytosis and eosinophilia. Anti-allergic activity was confirmed by inhibiting histamine induced contraction of smooth muscle. Mulmina® with its all variants offers over 4000 ORAC units per 200ml Tetra pak. Thus, fulfils daily requirement of antioxidants.
In Human Study, Mulmina® has improved immunity by increasing IgA and IgG. Mulmina® supplementation improves production of antibody postvaccination and maintain high antibody titer for longer duration. Mulmina® is only supplementation with proven antioxidant benefits in reducing oxidative stress in follicular fluids. Mulmina® increases levels of Superoxide dismutase (SOD), catalase (CAT) and Glutathione highlighting the antioxidant potential. Mulmina® helps to reduce C Reactive Protein (CRP) level, which indicates excellent anti-inflammatory activity. Mulmina® has a potential role in controlling the Cytokines levels and helps in reduction in inflammation. Studies have proved that Mulmina® increases Dopamine level (feel-good hormone).
Conclusion:
Mulmina® blend has proven efficacy in hastening recovery from disease, reducing inflammation and decreasing oxidative stress. over 1,200 patients have been tested in the various clinical trials, and no side effects have been reported. Overall, Mulmina® ® has demonstrated superiority as a supplement in diverse patient groups, providing improvement in oxidative stress and inflammation, with good safety and tolerability.
