Title : The effects of herbal supplement of Ginkgo biloba on brain edema, neurologic outcome and oxidative stress following traumatic brain injury in male rats
Abstract:
Background and Objectives: Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality throughout the world. It will probably become the third leading cause of death in the world by the year 2023. Despite extensive research, successful treatment for TBI has not been introduced yet. Neurotrophic factors and cognitive function of the brain are usually affected by herbal supplements. In previous studies, the role of ginkgo biloba in increasing of neurotrophic factor and improving of brain injury has been confirmed. In the current study, effects of Ginkgo biloba after diffuse traumatic brain injury was investigated.
Methods: In this experimental study, 30 male Wistar rats weighing 250-200 g randomly assigned to five groups sham, TBI, vehicle, ginkgo, TBI+ ginkgo. Moderate diffuse traumatic brain injury was induced by marmarou’s method. Ginkgo biloba extract was administrated orally 1 and 24 hours after TBI. Brain edema (using brain water content) was assessed 24 h after TBI. Evaluating short- time neurological (using veterinary coma scale; VCS) was assessed -1, ,4, 24 hours after TBI. Also, indexes of oxidative stress such as malondialdehyde (MDA) and total antioxidant capacity (TAC) was evaluated 24 hours after injury.
Results: Brain water content were less in ginkgo biloba treated groups comparison to vehicle and TBI groups. Ginkgo biloba increased V.C.S after traumatic brain injury in comparison to vehicle and TBI groups. The increasing in MDA and decreasing in TAC in TBI+ ginkgo group was lower than that of TBI and vehicle groups. Conclusion: This study showed that administration of ginkgo biloba reduced brain edema, oxidative stress after TBI. Following ginkgo biloba administration after injury improved neurologic outcome. Improvement after injury may be due to reducing inflammation following ginkgo biloba administration. The results suggest that using ginkgo biloba could be considered in TBI and perhaps other neurodegenerative disorders. However, further research is needed to find the mechanisms involved as well as safety of this inteeywords: Traumatic brain injury, Ginkgo biloba, Oxidative stress, Brain edame
Audience Take Away Notes:
- I try to share my latest findings with others and explain them clearly and the audience will find herbal supplements in treatment of nervous diseases.
- They will also learn that the dose and using time of herbal supplements are also involved.
- The results of this study also help herbal supplements to present a better and safety plan for maintaining of health to people.
