Abstract:
Introduction: Consumption of phytochemical-rich foods relates to the prevention of chronic diseases. In this study we assessed the dietary phytochemical index (PI) in liver enzymes and severity of fibrosis among non-alcoholic fatty liver disease patients.
Methods: This cross-sectional study was conducted on 150 patients with NAFLD. Fibrosis-4 index (FLB4), nonalcoholic fatty liver disease Fibrosis Score (NFS), AST, ALT, ALP, and GGT was measured. The usual intake of participants was measured using a validated semi-quantitative food frequency questionnaire and dietary PI was calculated. Multiple regression models were used to estimate mean difference changes in anthropometrics associated with various dietary PI.
Results: Participants’ mean ± SD of age and BMI were 39.23 ± 10.52 and 24.40 ± 2.64, respectively. We found that a higher score in DPI is associated with lower scores in NFS and FIB-4. Multivariate linear regression showed that there is an inverse association between DPI and AST, ALT, ALP, GGT, NFS and FIB-4.
Discussion: Higher dietary PI could effects on reduction of NFLD progression and improvement of metabolic parameters.
Keywords: Dietary phytochemical index, Non-alcoholic fatty liver disease, metabolic syndrome
Audience take away:
Our findings can be used to inform the development of strategies and dietary guidelines aimed at reducing NFLD progression.
Further studies should be conducted. In addition, prospective and interventional investigations are needed to clarify casual relationships.
