In medicine, a taxonomic revolution has taken place. The research for a precise COVID-19 treatment has already begun. Researchers have created a multitude of new disease subclassifications, fueled by the utopian vision of focused “precision” therapy and enabled by access to vast electronic health data sets, high-throughput multichannel, molecular diagnostic assays, and discoveries in disease biology. The time has come for a COVID-19 precision medicine strategy that combines translational science, subtype discovery, and a new taxonomy with clinical trial knowledge generation. The future of medicine will be shaped by personalized medicine, which places the patient at the center of attention.