Personalized medicine offers the potential to significantly improve health care by tailoring therapies to the specific needs of patients. However, it also causes changes in the economic and market landscape. The volume of scientific publications and a proven emphasis on genetic testing, health information management, biomarker discovery, and targeted medicines show that personalized medicine research and innovation are extensive and expanding. The market for molecular diagnostics is continuously expanding and diversifying. To overcome these challenges, short-term tactics to deploy programs that are simple and provide clear solutions, as well as long-term strategies to achieve systemic and cultural change, will likely be required.