The heart of drug discovery research is screening technologies. Because screening is so important in identifying and validating targets, the quality of the screening technique used can be a decisive factor in whether or not a new drug makes it to the clinic. To discover chemical compounds that can be manufactured and marketed, a variety of methods are used. Over the last 40 years, the complexity of medication development has skyrocketed. New drugs are developed through drug discovery. Drugs were formerly discovered mostly through discovering active components in traditional medications or by pure accident. Drug discovery nowadays entails hit screening, medicinal chemistry, and hit optimization to limit potential drug side effects (increasing affinity and selectivity). This stage of the medication development process also improves efficacy or potency, metabolic stability (half-life), and oral bioavailability.
In Vitro Models for Drug Screening
Title : Microemulsion based in situ gel of erythromycin for ocular ailments
Dasharath Muljibhai Patel, Graduate School of Pharmacy, India
Title : Nanomaterial-mediated systemically administered m-RNA-based gene therapy directed exclusively to cancer, present successes and future prospects
A C Matin, Stanford University, United States
Title : Thymoquinone-induced cellular and mitochondrial health in hepatocellular and cholangiocellular carcinoma
Consolato M Sergi, University of Ottawa, Canada
Title : Points to consider for the manufacturing of cell and gene therapies
Richard Denk, SKAN AG, Switzerland
Title : Pharmacological features of sparsentan, a novel dual endothelin and angiotensin receptor antagonist
Miroslav Radenkovic, University of Belgrade, Serbia
Title : Development and validation of RP-HPLC method for the dissolution study of tofacitinib in pharmaceutical solid dosage form
Narapereddy Krishna Prasad, Reckitt Benckiser LLC, United States
Title : Does erector spinae plane block improve respiratory outcomes in adults with rib fractures?
Katie Aldred, University of Liverpool, United Kingdom
Title : Interdisciplinary perspective towards therapeutic potential in antenatal care
Anita, DMIHER, India
Title : Augmented anti-atopic dermatitis effect of crisaborole nanoemulgel in 2,4-Di-nitrochlorobenzene induced (DNCB) atopic dermatitis (AD) in Balb/c mice
Dipti Srivastava, Hygia institute of pharmaceutical education and research, India
Title : Formulation, characterization and evaluation: Micellar loaded complex of cuminum cyminum to treat causing disease of COVID 19 (Respiratory Infection)
Rudra Pratap Singh Rajput, Royal College of Pharmacy, India