The relationship between DNA, genetics, and nutrition, often explored through nutrigenetics, reveals how genetic variations affect nutrient metabolism and disease predispositions. Certain genes influence how the body absorbs, processes, and utilizes nutrients, impacting dietary needs and health risks. For example, variations in the MTHFR gene can affect folate metabolism, while the APOE gene affects cholesterol processing, informing dietary recommendations for managing cholesterol. Understanding genetic-nutrient interactions enables personalized nutrition, allowing diets to be tailored to genetic profiles for optimal health outcomes. Research continues to uncover how dietary choices interact with genetic predispositions, aiding in the prevention and management of diet-related conditions through targeted nutrition.