The integration of metabolomics and systems biology in nutrition has revolutionized the way we understand the relationship between diet and metabolism. Metabolomics provides a snapshot of metabolic responses to dietary intake, uncovering biomarkers that reflect nutritional status and disease progression. Systems biology complements this by analyzing interactions within and across biological systems, shedding light on how nutrients influence gene expression, protein activity, and metabolic pathways. These tools allow for the development of tailored nutritional strategies to manage health conditions such as metabolic syndrome and inflammation. Metabolomics and Systems Biology in Nutrition empower researchers and clinicians to design evidence-based, individualized dietary plans for improved health outcomes