Macronutrient deficiencies arise when individuals do not consume adequate amounts of the essential macronutrients—carbohydrates, proteins, and fats—required for maintaining energy levels and supporting bodily functions. Such deficiencies can lead to a range of health problems, including fatigue, muscle wasting, and cognitive impairments. For instance, a lack of protein can result in conditions like kwashiorkor, characterized by swelling and weakened immune function, while insufficient intake of carbohydrates can lead to ketosis and reduced physical performance. Nutritional research into macronutrient deficiencies examines how dietary patterns, food security, and cultural habits contribute to these deficits. This research also explores dietary interventions, such as the use of fortified foods or supplements, to address deficiencies in populations at risk. Adequate macronutrient intake is crucial for overall health and preventing chronic conditions like malnutrition and metabolic diseases.