Nutrient-epigenetic dynamics explore how dietary components influence gene expression, affecting health and disease susceptibility without altering the genetic code itself. This interaction, known as epigenetics, shows that nutrients like folate, B vitamins, and polyphenols can affect DNA methylation and histone modification, processes that regulate gene activity. For example, folate contributes to methylation reactions, which are vital for DNA repair and cellular growth, while polyphenols may modify histones to influence genes associated with inflammation and aging. Epigenetic changes can be inherited, suggesting that diet has the potential to impact future generations. This knowledge is vital for the development of dietary strategies aimed at preventing diseases like cancer, cardiovascular disease, and neurological disorders. Through nutrient-epigenetic research, personalized nutrition can be further refined, potentially offering preventive measures and health optimization based on individual genetic and epigenetic profiles.