Nutrient-epigenetic interaction studies focus on how dietary components can influence epigenetic modifications, which in turn affect gene expression without altering the DNA sequence. This area of research has significant implications for understanding how nutrition impacts health and disease. Nutrients such as folate, vitamin B12, and polyphenols have been shown to affect DNA methylation and histone modifications, influencing cellular processes like inflammation and metabolism. These epigenetic changes can contribute to disease susceptibility and development, suggesting that dietary choices may have long-term effects on gene regulation. By exploring these interactions, researchers aim to uncover mechanisms through which nutrition can be harnessed to promote health and prevent chronic diseases.